丘志(zhì)海
博士，研究員(yuán)，研究組組長
緻力于開(kāi)發光和聲無創腦成像和神經調控技術，并将其應用于腦功能研究和腦疾病治療。
主要研究方向：
多尺度神經網絡成像和操控
Email: qiuzhihai@@gdiist.cn
個人簡介：
2019年畢業于香港理工(gōng)大(dà)學生(shēng)物(wù)醫學工(gōng)程專業，獲生(shēng)物(wù)醫學工(gōng)程博士學位。2019-2022年在美國斯坦福大(dà)學醫學院從事博士後研究。獲得多項國際會議（包括神經科學、生(shēng)物(wù)物(wù)理、生(shēng)物(wù)醫學工(gōng)程、光學工(gōng)程等領域權威國際會議）獎項。相關研究成果在PNAS、Cell Reports、iScience、Advanced Science、 Brain stimulation, Advanced Photonics Research、IEEE TUFFC、STAR Protocols等學術期刊上發表。主持國自然面上項目1項。申請中(zhōng)國發明專利6項，美國專利4項。受邀在牛津大(dà)學《經顱腦調控工(gōng)具書(shū)》撰寫超聲神經調控章節。是STAR Protocols雜(zá)志(zhì)的Advisory board member。
多尺度神經網絡成像和操控研究組：
目前主要聚焦超聲神經調控和超聲腦功能成像技術及其應用研究。
超聲波是一(yī)種較安全的能量形式，在腦功能成像和神經調控中(zhōng)顯示出越來越明朗的應用前景。平面波超聲可以快速對全腦的血流灌注進行成像，得到類似于血氧水平依賴性功能磁共振（BOLD-fMRI）信息。超聲系統相對簡單和小(xiǎo)巧，相比于功能核磁可以用較低的成本實現自由移動生(shēng)物(wù)體(tǐ)的全腦功能成像。另一(yī)方面，研究顯示低能量低頻(pín)率聚焦超聲作爲一(yī)種機械波，可以打開(kāi)機械敏感通道蛋白(bái)，在神經刺激、神經-免疫調控等方面都有很大(dà)的應用前景。我(wǒ)(wǒ)們從中(zhōng)發展起來了基于MscL-G22s（一(yī)種細菌中(zhōng)發現的機械敏感通道蛋白(bái)）的超聲遺傳學技術，已經被法國學者獨立驗證，日益受到關注。在這些研究基礎上，我(wǒ)(wǒ)們正緻力于開(kāi)發全聲學的跨尺度神經網絡成像和操控技術（包括基于超聲遺傳學的全腦神經網絡解構方法、全腦-脊成像和刺激技術），并探索它們在臨床前和臨床轉化中(zhōng)的應用。
此外(wài)，爲了拓展光和聲在顱骨和腦組織中(zhōng)的穿透深度，我(wǒ)(wǒ)們正在開(kāi)發光和聲的波前調控技術，希望推動光和聲相關技術在基礎研究和臨床轉化中(zhōng)的應用。
本課題組長期招聘聯合培養博士生(shēng)，FPGA工(gōng)程師，感興趣的同學，請郵件聯系。
代表論著：
[1] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Derek King Fung Wong, Yong Wu, Xuandi Hou, Jinghui Guo, Lei Sun*. Modulation of deep neural circuits with sonogenetics. PNAS, 2023, 120(23): e2220575120
[2] Jiejun Zhu, Quanxiang Xian, Xuandi Hou, Kin Fung Wong, Tingting Zhu, Zihao Chen, Dongming He, Shashwati Kala, Suresh Murugappan, Jianing Jing, Yong Wu, Xinyi Zhao, Danni Li, Jinghui Guo, Zhihai Qiu*, Lei Sun*. The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. PNAS, 2023, 120(18): e2300291120
[3] Tianyi Liu, Mi Hyun Choi, Jiejun Zhu, Tingting Zhu, Jin Yang, Na Li, Zihao Chen, Quanxiang Xian, Xuandi Hou, Dongmin He, Jinghui Guo, Chunlong Fei, Lei Sun, Zhihai Qiu*. Sonogenetics: Recent advances and future directions. Brain stimulation, 2022, 15(5): 1308-1317
[4] Na Li, Zihao Chen, Jiejun Zhu, Mi Hyun Choi, Jin Yang, Zhen Yuan, Lei Sun, Chunlong Fei, Zhihai Qiu*. Measuring sound velocity based on acoustic resonance using multiple narrow band transducers. Heliyon, 2023, 9(3): 230145
[5] Zhihai Qiu, Mihyun Choi, Ningrui Li, Kim Butts Pauly, Direct neural activation by ultrasound. (In preparation)
[6] Zhihai Qiu, Shashwati Kala, Jinghui Guo, Quanxiang xian, Jiejun Zhu, Ting Zhu, Xuandi Hou, King Fung Wong, Minyi Yang, Haoru Wang, Lei Sun*. Targeted neurostimulation in mouse brains with non-invasive ultrasound. Cell Reports, 2020, 32(7), 108033
[7] Zhihai Qiu, Jinghui Guo, Shashwati Kala, Jiejun Zhu, Quanxiang Xian, Weibao Qiu, Guofeng Li, Ting Zhu, Long Meng, Rui Zhang, Hsiao Chang Chan, Hairong Zheng*, Lei Sun*. The mechanosensitive ion channel Piezo1 significantly mediates in vitro ultrasonic stimulation of neurons. iScience, 2019, 21: 448-457
[8] Xuandi Hou#,Zhihai Qiu#, Jinghui Guo, Ting Zhu, Lei Sun*, Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Advanced Science, 2021, 2101934
[9] Keith R Murphy, Jordan S Farrell, Juan L Gomez, Quintin G Stedman, Ningrui Li, Steven A Leung, Cameron H Good, Zhihai Qiu, Kamyar Firouzi, Kim Butts Pauly, Butrus Pierre T Khuri-Yakub, Michael Michaelides, Ivan Soltesz, Luis de Lecea. A tool for monitoring cell type–specific focused ultrasound neuromodulation and control of chronic epilepsy. PNAS, 2022, 119(46): e2206828119
[10] Tianting Zhong#, Zhihai Qiu#, Jinhui Guo, Huanhao Li, Zhipeng Yu, Shengfu Cheng, Yingying Zhou, Jiejun Zhu, Jie Tian*, Lei Sun*, and Puxiang Lai*, Spatiotemporally engineered neuron stimulation (STENS) through mouse skull with a wavefront shaping-empowered multimode fiber. Advanced photonic research, accepted
[11] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Jiejun Zhu, Jinghui Guo and Lei Sun*, Protocol for the sonogenetic stimulation of mouse brain by non-invasive ultrasound. STAR Protocols, 2021, 2 (2), 100393
[12] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Jinghui Guo, and Lei Sun*, Behavioral and functional assessment of ultrasound neuromodulation on Caenorhabditis elegans. IEEE TUFFC, 2021, 68(6), 2150 – 2154
[13] Jinghui Guo, Yong Wu, Zhiyong Gong, Xixi Chen, Fei Cao, shashwati Kala, Zhihai Qiu et al, Photonic nanojet-mediated optogenetics, Advanced Science, accepted.
[14] Zhaoxi Li, Dafeng Wang, Chunlong Fei*, Zhihai Qiu et al, The Forbidden Band and Size Selectivity of Acoustic Radiation Force Trapping, iScience, 2020, 2021, 24(1): 101988.
